Abex - Guaiphenesin, Pseudoephedrine & Triprolidine-Cough Expectorant

Abex Syrup

Description:

Abex®Syrup is a mixture of expectorant, bronchodilator / decongestant and antihistamine. Guaiphenesin has an expectorant action and is thought to reduce sputum viscosity by increasing the volume and water content of the bronchial secretion, thereby facilitating the expectoration of sputum. Pseudoephedrine has direct and indirect sympathomimetic activity and is an effective upper respiratory decongestant, producing decongestion within 30 minutes which lasts for at least 4 hours. Triprolidine is a potent competitive histamine H1-receptor antagonist of the pyrrolidine group. Abex®Syrup is absorbed from the gastrointestinal tract. Guaiphenesin is metabolised and excreted in the urine. Pseudoephedrine is largely excreted unchanged in the urine together with small amount of its hepatic metabolite and Triprolidine is metabolised in the liver and excreted usually as metabolites in the urine.

Composition:

Each 5ml of Abex®Cough Syrup contains Guaiphenesin BP 100 mg, Pseudoephedrine HCl BP 30 mg and Triprolidine HCl BP 1.25 mg.

Indication:

Abex®Syrup is a cough preparation indicated for the symptomatic relief of upper respiratory tract disorder accompanied by productive cough which are benefited from the administration of an antihistamine, a decongestant and an expectorant combination.

Dosage and Administration:

Adult and Children over 12 years : 2 teaspoonful 3 times daily.

Children:6-12 years : 1 teaspoonful 3 times daily 2-5 years : 1/2 teaspoonful 3 times daily or as directed by the physician.

Precaution:

Abex®cough syrup may cause drowsiness; so patients should not drive or operate machineries. Concomitant use of alcohol and other centrally active durg should be avoided. Caution should be exercised in patients with hypertension, heart disease, diabetes, hyperthyroidism, elevated intraocular pressure and prostatic enlargement. The drug should not be used for persistent or chronic cough as occur with smoking, asthma or emphysema or where cough is accompanied by excessive secretions unless directed by a physician.

Use in pregnancy :

Caution should be exercised by balancing the potential benefit of treatment of the mother against any possible hazards to the developing foetus.

Side effect:

Central nervous system depression or excitation may occur, drowsiness being reported most frequently. Sleep disturbance and rarely hallucination have been reported. Skin rashes with or without irritation, tachycardia, dryness of mouth, nose and throat have occasionally been reported. Urinary retention has been reported occasionally in man receiving Pseudoephedrine; prostatic enlargement could have been an important predisposing factor.

Contraindication:

Abex®is contraindicated in patients with a known hypersensitivity to Guaiphenesin, Pseudoephedrine or Triprolidine. It is contraindicated in patients with severe hypertension or severe coronary artery disease. Also, contraindicated in persons who are taking or have taken monoamine oxidase inhibitors within the preceding two weeks.

How supplied:

Abex®Cough Syrup : 100 ml Syrup available in bottle.

Manufacturer’s Source: IBN SINA