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Description:
Algirex is the preparation of Etoricoxib. It is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. It is a potent, orally active, highly selective cyclooxygenase-2 (COX-2) inhibitor within and above the clinical dose range. COX-2 has been shown to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. Selective inhibition of COX-2 by Etoricoxib decreases these clinical signs and symptoms with decreased GI toxicity and without effects on platelet function.
Algirex is the preparation of Etoricoxib. It is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. It is a potent, orally active, highly selective cyclooxygenase-2 (COX-2) inhibitor within and above the clinical dose range. COX-2 has been shown to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. Selective inhibition of COX-2 by Etoricoxib decreases these clinical signs and symptoms with decreased GI toxicity and without effects on platelet function.
Composition:
Algirex® 60 Tablet: Each film-coated tablet contains Etoricoxib INN 60 mg.
Algirex® 90 Tablet: Each film-coated tablet contains Etoricoxib INN 90 mg.
Algirex® 120 Tablet: Each film-coated tablet contains Etoricoxib INN 120 mg.
Algirex® 60 Tablet: Each film-coated tablet contains Etoricoxib INN 60 mg.
Algirex® 90 Tablet: Each film-coated tablet contains Etoricoxib INN 90 mg.
Algirex® 120 Tablet: Each film-coated tablet contains Etoricoxib INN 120 mg.
Indication:
Acute pain and inflammation, Chronic musculo-skeletal pain, Osteoarthritis, Rheumatoid arthritis, Acute gouty arthritis, Primary dysmenorrhoea, Ankylosing spondylitis.
Acute pain and inflammation, Chronic musculo-skeletal pain, Osteoarthritis, Rheumatoid arthritis, Acute gouty arthritis, Primary dysmenorrhoea, Ankylosing spondylitis.
Dosage and
Administration:
Adult and adolescent (over 16 years):
Arthritis:
Osteoarthritis: 60 mg once daily, Rheumatoid arthritis: 90 mg once daily, Acute gouty arthritis: 120 mg once daily.
Analgesia:
Acute pain associated with dental surgery: 120 mg once daily. Primary dysmenorrhoea, Chronic musculoskeletal pain, including chronic low back pain: 60 mg once daily.
Adult and adolescent (over 16 years):
Arthritis:
Osteoarthritis: 60 mg once daily, Rheumatoid arthritis: 90 mg once daily, Acute gouty arthritis: 120 mg once daily.
Analgesia:
Acute pain associated with dental surgery: 120 mg once daily. Primary dysmenorrhoea, Chronic musculoskeletal pain, including chronic low back pain: 60 mg once daily.
Contraindication:
Patients with known hypersensitivity to Etoricoxib or to any of the excipients of this medicinal product. Active peptic ulceration or gastro-intestinal bleeding, severe hepatic dysfunction.
Children and adolescents under 16 years of age.
Patients with inflammatory bowel disease and severe congestive heart failure.
Patients with known hypersensitivity to Etoricoxib or to any of the excipients of this medicinal product. Active peptic ulceration or gastro-intestinal bleeding, severe hepatic dysfunction.
Children and adolescents under 16 years of age.
Patients with inflammatory bowel disease and severe congestive heart failure.
Precaution:
Decreased kidney function and liver function, dehydration, hypertension, history of heart failure, perforation and people over 65 years of age.
Decreased kidney function and liver function, dehydration, hypertension, history of heart failure, perforation and people over 65 years of age.
Side
Effect:
Common side effects are dizziness, headache, gastro-intestinal disorders (e.g., abdominal pain, flatulence, heartburn), diarrhoea, dyspepsia, nausea, asthenia, fatigue, flu-like symptoms. Rare side effects are oedema, weight gain, anxiety, blurred vision, hypertension, epistaxis, dyspnoea, constipation, vomiting, muscle cramps, and chest pain.
Common side effects are dizziness, headache, gastro-intestinal disorders (e.g., abdominal pain, flatulence, heartburn), diarrhoea, dyspepsia, nausea, asthenia, fatigue, flu-like symptoms. Rare side effects are oedema, weight gain, anxiety, blurred vision, hypertension, epistaxis, dyspnoea, constipation, vomiting, muscle cramps, and chest pain.
Drug
Interaction:
Warfarin, ACE inhibitor, Rifampicin, Lithium, birth control pills, Methotrexate, Digoxin.
Warfarin, ACE inhibitor, Rifampicin, Lithium, birth control pills, Methotrexate, Digoxin.
Use in
Pregnancy and Lactation:
Not recommended.
Not recommended.
Storage:
Keep in a cool and dry place, protected from light and moisture.
Keep in a cool and dry place, protected from light and moisture.
Presentation:
Algirex® 60 Tablet: Each box contains 3 x 10's tablet in Alu-Alu blister strip.
Algirex® 90 Tablet: Each box contains 2 x 10's tablet in Alu-Alu blister strip.
Algirex® 120 Tablet: Each box contains 2 x 10's tablet in Alu-Alu blister strip.
Manufacturer’s Source: IBN SINA
Algirex® 60 Tablet: Each box contains 3 x 10's tablet in Alu-Alu blister strip.
Algirex® 90 Tablet: Each box contains 2 x 10's tablet in Alu-Alu blister strip.
Algirex® 120 Tablet: Each box contains 2 x 10's tablet in Alu-Alu blister strip.
Manufacturer’s Source: IBN SINA
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